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the serotonin receptors: from molecular pharmacology to human therapeutics
Bryan L. Roth
(Ilustrado por)
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Humana
· Tapa Blanda
the serotonin receptors: from molecular pharmacology to human therapeutics - Roth, Bryan L.
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Reseña del libro "the serotonin receptors: from molecular pharmacology to human therapeutics"
A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
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