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transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy
C. -H Heldin
(Prefacio de)
·
Sonia B. Jakowlew
(Ilustrado por)
·
Humana
· Tapa Blanda
transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy - Heldin, C. -H ; Jakowlew, Sonia B.
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Reseña del libro "transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy"
Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.
