1. Clinical presentation of myeloma bone disease (MBD) 2. Imaging of myeloma bone disease 3. Bone Markers in MBD 4. Radiation therapy for MBD 5. Surgical treatment (kyphoplasty, vertebroplasty and standard surgery) 6. Pathophysiology of MBD 7. Osteoclast activation in MBD 8. Osteoblast Suppression in MBD 9. Animal models of MBD 10. Bisphopsphonate treatment of MBD 11. Osteonecrosis of the jaw in myeloma 12. Novel therapies for MBD (Denosumab, velcade and imids)