The book mostly follows the lives of Plumfield boys who were introduced in Little Men, particularly Tommy, Emil, Demi, Nat, Dan, and Professor Bhaer and Jo's sons Rob and Teddy, although the others make frequent appearances as well. The book takes place ten years after Little Men. Dolly and George are college students dealing with the temptations of snobbery, arrogance, self-indulgence and vanity. Tommy becomes a medical student to impress childhood sweetheart Nan, but after "accidentally" falling in love with and proposing to Dora, he joins his family business.