Over the years, different incarnations of the Justice Society of America and the Justice League of America have fought together to safeguard the world against all types of threats. Celebrating this camaraderie, the two teams decide to get together for a traditional Thanksgiving meal. But when the Seven Deadly Enemies of Man possess different members of the teams, their festivities are abruptly ended. Featuring Superman, Batman, Green Lantern, and the Flash, JLA/JSA: VIRTUE & VICE presents a team-up of epic proportions as three generations of heroes take on the wickedness of Sloth, Gluttony, Lust, Anger, Pride, Envy and Greed.